Why Generic Pain Creams Keep Failing You.

The problem with one size fits all pain relief: Most over-the-counter pain creams contain one or two active ingredients at fixed concentrations. But your chronic back pain involves different mechanisms than someone else's arthritis or neuropathy. Your pain intensity, skin sensitivity, and response to medications are unique to you.

The solution:Physician-formulated combinations that address multiple pain pathways simultaneously, with concentrations customized to your specific condition and needs.

We combine complementary ingredients that target different aspects of your pain from inflammation, nerve signals, muscle tension, and tissue damage. The total relief often exceeds what any single ingredient could provide alone without the side effects of pills and tablets. This is supported by clinical research showing synergistic effects when pain relief mechanisms work together.

$79/month supply. No copays. No insurance. No hidden fees.

Personalized compounded pain relief cream formula

Meet the Ingredients that Power Your Relief.

Your doctor and pharmacist craft your formula based on your pain profile—where it hurts, how it feels, and what has or hasn't worked before. It's not generic. It's built for you. And that's what makes the difference.

Immediate relief agents

Camphor: Rapid Pain Signal Interference

Clinical mechanism: Camphor activates thermoreceptors and mechanoreceptors in your skin, creating sensations that compete with pain signals for neural pathway access. This process, known as the Gate Control Theory, explains why competing sensations can effectively reduce pain perception.

What you experience: Within 2-5 minutes of application, you'll notice a warming sensation accompanied by decreased pain intensity. The tight, aching sensation in affected areas begins to ease as camphor increases local blood circulation and creates analgesic effects.

Evidence based benefits:

Rapid onset of pain relief (2-5 minutes)
Enhanced penetration of other active ingredients
Improved circulation to promote tissue healing
Natural antimicrobial properties for skin health

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

“Camphor is one of my go-to ingredients for arthritis patients. It creates this beautiful warming sensation that actually improves circulation to the joint capsule. Patients tell me it’s like their joints finally get to breathe again.”

Personalized concentrations, tailored to your needs.

Mild pain or sensitive areas:

0.1-1% for daily maintenance.

Mild- moderate conditions:

3-5% for standard relief.

Severe chronic pain:

8-11% for intensive management.

Severe chronic pain:

8-11% for intensive management.

Immediate relief agents

Menthol: Neural Pathway Modulation

How it provides relief: Menthol activates TRPM8 cold receptors, creating cooling sensations that can block up to 40% of pain signal transmission within minutes. This receptor activation effectively "crowds out" pain signals competing for the same neural pathways.

Quality specifications: We use pharmaceutical-grade L-menthol (the natural isomer) which provides superior skin penetration and duration compared to synthetic alternatives commonly used in commercial products.

Research validation: Studies demonstrate that menthol concentrations above 8% provide analgesic effects comparable to topical NSAIDs for certain musculoskeletal conditions, with faster onset of action.

May help with:

Burning nerve pain.
Inflammatory conditions.
Muscle tension where cooling provides both immediate comfort and therapeutic benefit.

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"The difference between natural L-menthol and synthetic menthol is remarkable. Natural menthol not only penetrates 30% deeper, but patients consistently report longer-lasting relief. When I'm formulating for chronic pain patients, this ingredient choice can make the difference between a good formulation and an exceptional one."

Personalized concentrations, tailored to your needs.

Daily maintenance

1-4% for ongoing pain management.

Standard therapeutic dose

6-10% for moderate pain relief.

Maximum concentration

11-14% for severe acute pain or neuropathic conditions.

Maximum concentration

11-14% for severe acute pain or neuropathic conditions.

Local Anesthetic

Lidocaine: Targeted Neural Blockade

How it works: Lidocaine blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and propagation of pain signals. This creates localized numbness without affecting surrounding healthy tissue or causing systemic effects.

Evidence base: Clinical trials demonstrate that 5% lidocaine provides pain relief equivalent to oral gabapentin for neuropathic pain, with significantly fewer side effects and faster onset.

Safety profile: Topical lidocaine achieves therapeutic local concentrations while maintaining minimal systemic absorption (less than 3% of applied dose enters circulation).

Clinical process:

Absorption phase (5-15 minutes): Lidocaine penetrates skin barrier
Binding phase (15-30 minutes): Molecules bind to sodium channels
Therapeutic effect (30+ minutes): Complete blockade of pain signal transmission
Duration: 2-4 hours of significant numbness and pain relief

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations, tailored to your needs.

Gentle maintenance

5-6% for chronic daily management.

Standard therapy

7-8% for acute injuries or moderate pain.

High-concentration

9-10% for severe inflammation or breakthrough pain.

High-concentration

9-10% for severe inflammation or breakthrough pain.

Anti-Inflammatory Agents

Diclofenac: Selective COX-2 Inhibition

Clinical advantage: Diclofenac provides potent anti-inflammatory effects by selectively inhibiting cyclooxygenase-2 (COX-2) enzymes, which produce inflammatory prostaglandins. Topical application delivers 10-20 times higher tissue concentrations than oral administration.

How it stops inflammation in its path: By blocking prostaglandin E2 production directly in affected tissues, diclofenac reduces swelling, heat, and inflammatory pain at the source while minimizing systemic exposure.

Clinical outcomes: Research shows topical diclofenac provides equivalent pain relief to oral NSAIDs for arthritis and soft tissue injuries, with significantly reduced risk of gastrointestinal, cardiovascular, and renal side effects.

Ideal for:

Osteoarthritis and rheumatoid arthritis management
Sports injuries with significant inflammation
Tendinitis and soft tissue inflammatory conditions
Acute injury management

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Diclofenac is incredibly effective topically because it concentrates exactly where the inflammation is happening. I often tell patients that applying 3% diclofenac cream delivers more anti-inflammatory power to their arthritic joint than swallowing a 75mg pill, but without any of the stomach or kidney concerns."

Personalized concentrations of diclofenac, tailored to your needs.

Maintenance therapy

1-2% for ongoing inflammatory conditions

Standard treatment

2.5-3% for moderate arthritis or acute injuries

High potency therapy

3.5-4% for severe inflammatory episodes

High potency therapy

3.5-4% for severe inflammatory episodes

Anti-Inflammatory Agents

Ibuprofen: Broad-Spectrum Anti-Inflammatory

Multi-pathway approach: Ibuprofen inhibits both COX-1 and COX-2 enzymes, providing comprehensive inflammatory control. Its dual-pathway inhibition makes it particularly effective for mixed inflammatory and mechanical pain conditions.

Enhanced topical delivery: Our advanced formulations achieve therapeutic tissue concentrations that would require 400-600mg oral doses, using only 40-80mg of topical medication with minimal systemic absorption.

Clinical benefits:

Broad-spectrum inflammatory control
Excellent muscle tissue penetration
Reduced systemic side effect profile
Familiar safety data from decades of clinical use

Ideal for:

Sports and overuse injuries
General arthritic conditions
Post-exercise inflammation management
Mixed pain conditions involving multiple tissue types

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations of ibuprofen tailored to your needs:

Gentle maintenance

5-6% for chronic daily management.

Standard therapy

7-8% for acute injuries or moderate pain.

High-concentration

9-10% for severe inflammation or breakthrough pain.

High-concentration

9-10% for severe inflammation or breakthrough pain.

Anti-Inflammatory Agents

Ketoprofen: Deep Tissue Penetration

Unique properties: Ketoprofen's lipophilic characteristics enable superior skin penetration and sustained tissue concentrations. It provides both COX inhibition and lipoxygenase pathway modulation for comprehensive inflammatory control.

Extended duration: Single applications provide 8-12 hours of therapeutic effect due to ketoprofen's tissue binding properties and sustained release from skin depot sites.

Clinical advantages:

Superior penetration to deep muscles and joints
Dual anti-inflammatory pathway inhibition
Extended duration requiring fewer daily applications
Excellent safety profile for long-term use

Primary indications:

Deep arthritis pain in large joints
Chronic conditions requiring sustained relief
Sports medicine applications
Post-surgical pain management

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations of ketoprofen tailored to your needs:

Maintenance

2.5-5% for chronic condition management.

Standard therapy

10-15% for acute pain and inflammation.

Maximum strength

16-20% for severe, deep tissue pain.

Maximum strength

16-20% for severe, deep tissue pain.

Neuropathic Pain

Amitriptyline: Neuropathic Pain Specialist

Multi-modal approach: Amitriptyline provides neuropathic pain relief through sodium channel blockade, norepinephrine reuptake inhibition, and NMDA receptor antagonism—addressing both peripheral and central pain sensitization.

Clinical evidence: Over 100 published studies demonstrate amitriptyline's effectiveness for neuropathic pain conditions, with topical application providing 60-80% of oral efficacy without systemic side effects.

Neuropathic pain mechanisms addressed:

Peripheral nerve hyperexcitability
Central pain sensitization
Descending pain inhibition enhancement
Sleep disturbance from nerve pain

Primary applications:

Diabetic peripheral neuropathy
Post-herpetic neuralgia (shingles pain)
Fibromyalgia burning and hypersensitivity
Complex regional pain syndrome

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations of amitriptyline tailored to your needs:

Initial therapy

1-2% for mild neuropathic pain.

Standard treatment

3% for moderate nerve pain conditions.

Maximum strength

4-5% for severe, refractory neuropathic pain.

Maximum strength

4-5% for severe, refractory neuropathic pain.

Muscle Relaxants

Baclofen: GABA-B Receptor Agonist

Mechanism: Baclofen mimics gamma-aminobutyric acid (GABA), your body's primary inhibitory neurotransmitter, at muscle nerve endings. This reduces excessive nerve impulses that cause muscle spasms and chronic tension.

Clinical effects:

Direct muscle fiber relaxation
Reduced involuntary muscle contractions
Interruption of pain-spasm cycles
Improved functional mobility

Topical advantages: Eliminates the sedation, dizziness, and withdrawal concerns associated with oral baclofen while providing targeted muscle relaxation where needed.

Therapeutic applications:

Chronic back and neck muscle spasms
Sports-related muscle strains
Fibromyalgia muscle tenderness
Spasticity management

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations of baclofen tailored to your needs:

Daily maintenance

2-4% for chronic muscle tension.

Standard treatment

5-7% for moderate spasms.

Maximum therapy

8-10% for severe muscle spasticity.

Maximum therapy

8-10% for severe muscle spasticity.

Muscle Relaxant

Cyclobenzaprine: Centrally Acting Muscle Relaxant

Dual mechanism: Cyclobenzaprine reduces muscle hyperactivity through brainstem modulation while providing additional analgesic effects through norepinephrine and serotonin pathway enhancement.

Clinical benefits:

Effective for acute muscle spasm episodes
Addresses chronic muscle tension patterns
Supports improved sleep quality
Mood-stabilizing effects for pain-related stress

Evidence base: Topical cyclobenzaprine provides equivalent muscle relaxation to oral formulations without systemic sedation or anticholinergic side effects.

Optimal uses:

Acute back and neck strain
Whiplash and trauma recovery
TMJ and facial muscle tension
Tension headache management

Is a personalized formula for you?

Take the quick quiz to see if Twinge Health is right for you.

Dr. Javed

PharmD, RPh, Co-Founder of Twinge Health

"Cyclobenzaprine is particularly effective for acute muscle spasms. Those sudden 'I can't move' episodes. Topical application gives patients the rapid muscle relaxation they need for acute episodes without the next day grogginess that makes oral Flexeril so problematic for working adults."

Personalized concentrations of cyclobenzaprine tailored to your needs:

Maintenance

1-2% for ongoing muscle tension.

Standard

3% for moderate spasm and acute strain.

High-potency

4-5% for severe muscle spasm episodes.

High-potency

4-5% for severe muscle spasm episodes.

Built to relieve.
Designed to fit your life.

From ingredients to applicator, every part of Twinge is built to deliver fast, lasting comfort—without the side effects, the mess, or the guesswork. It's designed to fit into your routine and bring relief you can count on, day after day.

Gentle on skin.
Clean on contact.

Hypoallergenic, fragrance-free base that dries fast with no greasy regret.

Made just for you.
Not the aisle.

Every formula is built around your pain location, sensation, and severity.

Get the exact dose, every time

Twist, click, apply. No waste. No second-guessing

Targets pain, not your whole body and it lasts longer than hope.

This is NOT your average cream. This one sticks with you when the others wear off without side effects of oral medications.

Dizziness

GI Bleeds

Liver Damage

Kidney Damage

Addiction

Blurred Vision

Headache

Heart rate

Confusion

Constipation

Abdominal Pain

Difficulty Breathing

Opioid-free.
Non-habit forming.

Strong enough to work. Safe enough to use daily.

Skip the clinic.
Get relief anyway.

No lines. No awkward video calls. Just a short online visit and fast delivery.

Built by experts.
Backed by real access.

Pharmacist-formulated. Doctor-approved. And you can message a real expert anytime.

See What Others Say

Select a condition to see what others say about our products.

Tina

Retired Teacher, 63

Got my mornings back

Mornings used to be the worst. I'd sit on the edge of the bed just trying to will my knees to bend. This cream gave me my mornings back.

Carlos, 59

Auto Technician

Small miracle for my hands

I tried everything for my stiff hands. Within a few days of using this, I could open jars again without wincing. It felt like a small miracle.

Janice, 46

Data Analyst

No more stack of pain meds needed

The swelling in my wrists made typing unbearable. Now I can get through a workday without reaching for pain meds.

Leroy, 71

Veteran

Walking downstairs is easier!

I used to dread walking downstairs. The ache in my knees was awful. Since using this cream, it's been so much easier to move.

Miriam, 68

Home Gardener

Back to my favorite hobby

Arthritis made gardening painful. This took the edge off enough that I got back to my favorite hobby without needing to push through pain.

Robert, 65

Retired Carpenter

Can play with grandkids again!

My hip pain was keeping me from playing with my grandkids. This cream lets me get down on the floor and back up without agony.

Patricia, 58

Nurse

Sleep through the night!

My shoulder pain used to wake me up constantly. Now I can sleep through the night and wake up feeling refreshed.

Michael, 62

Sales Representative

Can drive without pain!

My back pain made driving unbearable. This cream lets me sit comfortably for long drives to visit family.

Sandra, 55

Administrative Assistant

Back to daily walks!

My ankle arthritis was keeping me from my daily walks. This cream has me back on the trails and feeling mobile again.

Matt

Physician, 52

Relieved my chronic lower back pain in days

As a doctor, I was skeptical, but Twinge really eased my lumbar pain fast without side effects.

Amanda, 45

Receptionist

I can sit all day without discomfort again

My back would ache by noon. Since using Twinge, workdays feel manageable again.

Jeff, 80

Retired

Helps me stay active and avoid the cane

My lower back stiffness made walking hard. Twinge gave me real relief within a week.

Theresa, 56

Accountant

Finally, something that actually targets the pain

I've tried everything for back spasms. This cream worked better than anything my doctor prescribed.

Paul, 52

Carpenter

Perfect for long days on the job site

After years of heavy lifting, my back was wrecked. Twinge made a noticeable difference fast.

LauraAnne, 59

Social Worker

Quick, easy relief for tension in my spine

Stress builds in my back by afternoon. Twinge is the only thing that calms it quickly.

Ani, 38

Web Developer

Soothing relief after long hours at my desk

Sitting all day caused daily backaches. I apply Twinge at night and wake up pain-free.

Derek, 60

General Manager

Works better than anything I've tried before

I've had recurring back issues for decades. This cream made a real difference after two uses.

Yao, 47

Engineer

Surprised by how well it worked for me

I expected mild relief, but my lower back pain almost vanished. Will definitely keep using it.

Kevin

High School Coach, 34

Helped my shoulder pain after years of pitching

I've had rotator cuff pain since college. Twinge reduced the inflammation better than anything else.

Marisol, 29

Personal Trainer

Great for recovery after intense training sessions

I use Twinge on my knees post-leg day. It cuts soreness in half by the next morning.

Dennis, 48

Banker

Finally relieved my tennis elbow flare-ups

Pickleball left me with constant elbow pain. This cream actually gives lasting relief.

Natalie, 41

Nurse

My IT band pain is finally under control

Running long distances always caused hip pain. Twinge helps me recover without needing painkillers.

Trevor, 38

Freelance Photographer

Helped my wrist pain after daily camera use

Holding a camera all day wrecked my joints. After two weeks with Twinge, I feel 10 years younger.

Renee, 33

Yoga Instructor

Calms muscle strain without affecting flexibility

I strained a hamstring last month—Twinge eased the tightness without dulling muscle sensitivity like pills do.

Jalen, 27

Bartender

Relieved my aching knees from standing all shift

Long shifts and constant motion wore out my joints. This cream brought the swelling down fast.

Lexi, 36

Dancer

An essential part of my post-rehearsal routine

I got repetitive strain from dance rehearsals. Twinge soothes it so I can keep performing.

Marcus, 43

Plumber

Worked wonders on my overworked lower back

Years of bending and lifting left my back sore daily. Twinge provided deep relief without stiffness.

Daniel

Chef, 46

Helped my heel pain after long shifts

I'm on my feet 12 hours a day. Twinge worked fast on my sore arches and heels.

Priya, 35

Retail Manager

No more burning feet at the end of day

My feet used to throb by closing time. This cream cools the pain almost instantly.

Howard, 62

Retired Mail Carrier

Helped my plantar fasciitis like nothing else

I've tried every insert and wrap. Twinge is the only thing that eased the stabbing heel pain.

Simone, 50

Flight Attendant

Instant relief after being on my feet all day

I rub it in after every shift. My arches don't ache anymore and swelling is down.

Brad, 39

Construction Worker

Foot pain used to keep me up at night

Long days in steel-toes wore my feet out. Twinge gave me relief I actually trust.

Jodi, 43

High School Teacher

Feels like I'm walking on clouds again

I didn't realize how much foot pain I'd normalized. Twinge brought real, lasting comfort.

Eli, 58

Mechanic

Took the sting out of years of foot strain

My job destroyed my arches. Twinge helps me get through the week without limping.

Roxanne, 32

Hiker

Best cream I've found for arch pain

I walk miles. Twinge soothes the dull aches and lets me recover faster.

Tomas, 49

Warehouse Packer

Finally some relief for my sore, tired feet

I've tried so many foot creams. None worked like this one. Twinge is now part of my routine.

Jordan

Electrician, 31

My go to for muscle pulls and tightness

I strained my calf last month. Twinge reduced the soreness and helped me bounce back faster.

Camille, 44

Pilates Instructor

Calms spasms without that menthol overload

I get mid-back spasms weekly. Twinge soothes the muscle without that overpowering medicinal smell.

Greg, 56

Bus Driver

Took care of my lower back spasms

Sitting all day triggered awful back spasms. After a week with Twinge, I could move normally again.

Keisha, 39

Massage Therapist

I recommend it

This cream can help with muscle knots. Twinge eases flare-ups better than most pro products.

Dylan, 28

EMT

Works fast on sudden muscle cramps

My quads seize up after long shifts. A little Twinge and the cramping dies down quickly.

Marcy, 53

Office Manager

Helps when my neck muscles lock up

I get stress-related neck spasms. This cream loosens the tension in under 20 minutes. Lifesaver.

Ahmed, 47

Taxi Driver

Loosened tight muscles

My upper back was locked for weeks. Twinge softened the knots and brought mobility back.

Sienna, 34

Store Manager

Best thing I've used for muscle tightness

Long hours and heavy lifting leave me stiff. Twinge relieves the ache without making my skin greasy.

Linda, 50

Mom

No more middle-of-the-night leg spasms

I'd wake up with severe leg cramps. I started using Twinge and they're practically gone.

Cheryl

Retired Teacher, 66

Numbness and tingling finally feel manageable

I have diabetic neuropathy in my feet. Twinge helps reduce the burning and pins-and-needles sensation.

Ron, 72

Retired Engineer

Takes the edge off my nerve pain

Shooting nerve pain in my legs used to wake me up. Twinge calms it down without pills.

Beatriz, 59

Legal Assistant

Calms the constant buzzing in my hands

I have carpal tunnel-related neuropathy. Twinge eases the nerve discomfort so I can actually type again.

Malik, 63

Delivery Driver

Helps my feet feel normal again

I have neuropathy from diabetes. I used to dread standing too long. This cream made the tingling and stinging far less intense.

Donna, 68

Artist

Better than the prescriptions I've tried

My doctor recommended a few creams, but only Twinge actually soothed my nerve pain consistently.

Henry, 61

HVAC Technician

Great for post-surgery nerve flare-ups

After back surgery, I had nerve pain down my leg. Twinge eased the burning within days.

Alina, 54

Bank Teller

I can wear shoes again comfortably

Neuropathy made even socks painful. Twinge dulled the sensitivity so I can walk without wincing.

Tomás, 58

Lab Tech

Actually helps with nerve zaps and jolts

I get these sudden nerve shocks in my calves. This cream tones them down better than anything else.

Joanne, 64

Seamstress

Nerve pain used to ruin my evenings

By dinner, my legs would burn and buzz. Twinge helped enough that I can finally relax at night.

Everything You're Wondering About Pain Relief That Actually Works

From appointments to disappointments, you've paid the price for pain relief that didn't deliver. Twinge is one cream that finally does. Here's everything you need to know.

View More FAQs

How does this work without seeing a doctor in person?

Is this actually prescription-strength, or just another cream?

How long does it take to feel relief?

What if it doesn't work for my pain?

Is this safe to use every day?

How is this different from other pain creams I've tried?

Do you take insurance?

How quickly will I get my cream?

What happens when I run out?

Can I use this with other medications I'm taking?

Still Have a Question?

If you have further questions, feel free to reach out to us. We're here to help you make the most of your Twinge experience.

Get in Touch

See How Twinge Compares to Your Current Pain Relief Regimen.

From appointments to disappointments, you've paid the price for pain relief that didn't deliver. Twinge is one cream that finally does.

OTC Creams

Rx Oral Pills

Twinge Cream

🛒 Access

Grab off the shelf and hope it helps.

Doctor visits, insurance hassle, and pharmacy pickup.

Quick telehealth visit with a doctor, shipped fast to your door.

⏱️ Time to Relief

Immediate if it's in stock.

Wait in line or wait for it to kick in.

Order from home and ships in two days with USPS Priority.

🧬 Personalization

Same formula for everyone.

One-size dose based on averages.

Tailored to your pain type, area, and history.

💪 Strength & Potency

Capped by over‑the‑counter limits.

Prescription strength, fixed dose.

Prescription strength, calibrated to your body needs.

😟 Side Effects

Can irritate your skin.

Risk of nausea, GI issues, liver/kidney strain, addiction.

Low systemic impact. No habit forming ingredients.

🎯 Targeting

Masks surface symptoms.

Distributes through your entire body.

Pain cream base penetrates deep into the skin to deliver powerful active ingredients right where it hurts.

⏳ Duration

Fades fast, needs reapplying often.

Wears off unevenly, leaves you chasing the next dose.

Stays active longer so you get through the day.

💰 Total Cost

$10 to $40 per tube.

$30 to $200 per month after copays and deductibles.

$79 / month

Includes custom cream, physician consult & shipping.

Questions? Chat with us

One Cream. One Price. Zero Nonsense.

From appointments to disappointments, you've paid the price for pain relief that didn't deliver. Twinge is one cream that finally does.

🛒 Access

⏱️ Time to Relief

🧬 Personalization

⚡ Strength & Potency

⚠️ Side Effects

🎯 Targeting

⏳ Duration

💰 Total Cost

OTC Creams:

$10 to $40 per tube.
Oral Pills:

$30 to $200 per month after copays and deductibles.
Twinge Custom Cream:

$79 all in — custom cream, physician consult, fast shipping.

$79/month supply. No copays. No insurance. No hidden fees.

Your Pain Relief Education Center

From skin penetration science to treatment comparisons—discover what medical experts know about effective pain relief.

8 Min Read

How to use the meter dose applicator: Twist, click, apply. No waste. Get the exact dose every time.

10 Min Read

Custom vs. Over-the-Counter: Why Personalized Arthritis Creams Work Better.

7 Min Read

Breaking the Oral Medication Cycle: How Topical Treatments Transform Arthritis Management.

Learn more about pain

Take Back Control from Pain—Today.

Start your telehealth visit now. Get a custom cream that targets your pain—delivered fast via 2 day priority shipping, all for $79. You're one click away.

Order Cream for $79

Shipping: 2-day priority included

FDA Disclaimer: Compounded medications are custom-made to meet the unique needs of each patient and are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. These formulations are prepared by licensed pharmacies in accordance with a prescription from a licensed healthcare provider. Your Twinge Health provider will determine whether a compounded topical pain cream is medically appropriate for your condition.

Emergency Substitution Disclaimer: Twinge Health services are not intended to replace emergency medical care. In case of an emergency, please call 911 or your local emergency services.

Arthritis & Joint Pain

Back Pain

Neuropathy

Foot & Heel Pain

Muscle Spasms & Strains

Sports & Overuse Injuries

Ready for Real Relief?

⌛ Limited Spots Remaining for September

Is Twinge Right for Your Pain?

Why Generic Pain Creams Keep Failing You.

The solution:Physician-formulated combinations that address multiple pain pathways simultaneously, with concentrations customized to your specific condition and needs.

Meet the Ingredients that Power Your Relief.

Your doctor and pharmacist craft your formula based on your pain profile—where it hurts, how it feels, and what has or hasn't worked before. It's not generic. It's built for you. And that's what makes the difference.

Camphor: Rapid Pain Signal Interference

Is a personalized formula for you?

Personalized concentrations, tailored to your needs.

Menthol: Neural Pathway Modulation

Is a personalized formula for you?

Personalized concentrations, tailored to your needs.

Lidocaine: Targeted Neural Blockade

Is a personalized formula for you?

Personalized concentrations, tailored to your needs.

Diclofenac: Selective COX-2 Inhibition

Is a personalized formula for you?

Personalized concentrations of diclofenac, tailored to your needs.

Ibuprofen: Broad-Spectrum Anti-Inflammatory

Is a personalized formula for you?

Personalized concentrations of ibuprofen tailored to your needs:

Ketoprofen: Deep Tissue Penetration

Is a personalized formula for you?

Personalized concentrations of ketoprofen tailored to your needs:

Amitriptyline: Neuropathic Pain Specialist

Is a personalized formula for you?

Personalized concentrations of amitriptyline tailored to your needs:

Baclofen: GABA-B Receptor Agonist

Is a personalized formula for you?

Personalized concentrations of baclofen tailored to your needs:

Cyclobenzaprine: Centrally Acting Muscle Relaxant

Is a personalized formula for you?

Personalized concentrations of cyclobenzaprine tailored to your needs:

Built to relieve. Designed to fit your life.

From ingredients to applicator, every part of Twinge is built to deliver fast, lasting comfort—without the side effects, the mess, or the guesswork. It's designed to fit into your routine and bring relief you can count on, day after day.

Gentle on skin. Clean on contact.

Made just for you. Not the aisle.

Get the exact dose, every time

Targets pain, not your whole body and it lasts longer than hope.

Opioid-free. Non-habit forming.

Skip the clinic. Get relief anyway.

Built by experts. Backed by real access.

See What Others Say

Select a condition to see what others say about our products.

Tina

Got my mornings back

Carlos, 59

Small miracle for my hands

Janice, 46

No more stack of pain meds needed

Leroy, 71

Walking downstairs is easier!

Miriam, 68

Back to my favorite hobby

Robert, 65

Can play with grandkids again!

Patricia, 58

Sleep through the night!

Michael, 62

Can drive without pain!

Sandra, 55

Back to daily walks!

Matt

Relieved my chronic lower back pain in days

Amanda, 45

I can sit all day without discomfort again

Jeff, 80

Helps me stay active and avoid the cane

Theresa, 56

Finally, something that actually targets the pain

Paul, 52

Perfect for long days on the job site

LauraAnne, 59

Built to relieve.
Designed to fit your life.

Gentle on skin.
Clean on contact.

Made just for you.
Not the aisle.

Opioid-free.
Non-habit forming.

Skip the clinic.
Get relief anyway.

Built by experts.
Backed by real access.